Ecsedy Monika, Schneider Miklos, Nemes Janos, Nemeth Janos, Recsan Zsuzsanna
Semmelweis University, Faculty of Medicine, Department of Ophthalmology , Budapest , Hungary , and.
Ocul Immunol Inflamm. 2014 Dec;22(6):454-60. doi: 10.3109/09273948.2014.883548. Epub 2014 Feb 24.
To report ocular symptoms and optical coherence tomography (OCT) features of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.
Case report of two Caucasian patients with POEMS, one of whom also had multicentric Castleman disease.
Both patients presented with edema on both optic disks, bilateral macular edema was seen in case 1, and peripapillary choroidal neovascularization was seen on the right side in case 2. OCT confirmed papilledema involving all retinal layers, with additional bilateral peripapillary serous retinal detachment involving the macula in both cases, and peripapillary CNV in case 2. Changes in retinal nerve fiber layer thickness, total peripapillary retinal thickness, and macular detachment were followed with OCT over the course of the disease and after administration of systemic therapy.
OCT examination of the optic nerve head and the macula has an important additional role in the diagnosis and follow-up of POEMS syndrome and Castleman disease.
报告多神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变（POEMS）综合征的眼部症状及光学相干断层扫描（OCT）特征。
两名患有POEMS综合征的白种患者的病例报告，其中一名患者还患有多中心Castleman病。
两名患者均出现双侧视盘水肿，病例1可见双侧黄斑水肿，病例2右侧可见视乳头周围脉络膜新生血管。OCT证实视乳头水肿累及所有视网膜层，两例均伴有累及黄斑的双侧视乳头周围浆液性视网膜脱离，病例2伴有视乳头周围脉络膜新生血管。在疾病过程中及全身治疗后，通过OCT跟踪视网膜神经纤维层厚度、视乳头周围视网膜总厚度和黄斑脱离的变化。
对视神经乳头和黄斑进行OCT检查在POEMS综合征和Castleman病的诊断及随访中具有重要的辅助作用。
