Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Biochem Biophys Res Commun. 2014 Mar 28;446(1):98-104. doi: 10.1016/j.bbrc.2014.02.058. Epub 2014 Feb 21.
Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The overexpression of miR-31 repressed the osteogenesis of hMSCs, whereas the downregulation enhanced this process. SATB2 was testified to be a direct target of miR-31, and its effects on the osteogenesis were also described. Most importantly, the knockdown of SATB2 attenuated miR-31's osteogenic effects. Taken together, our findings suggest that miR-31 regulates the osteogenesis of hMSCs by targeting SATB2.
探索调控人骨髓间充质干细胞（hMSCs）成骨的分子机制，将为改善与骨相关疾病的治疗带来更有效的方法。在这项研究中，我们分析了 miR-31 对 hMSCs 成骨的影响。miR-31 的过表达抑制了 hMSCs 的成骨，而下调则增强了这一过程。SATB2 被证明是 miR-31 的一个直接靶标，其对成骨的影响也被描述。最重要的是，SATB2 的敲低减弱了 miR-31 的成骨作用。总之，我们的研究结果表明，miR-31 通过靶向 SATB2 来调节 hMSCs 的成骨。
