Borzeix M G, Cahn R, Cahn J
SIR international, Département de Thérapeutique Expérimentale, Montrouge, France.
Prostaglandins. 1988 May;35(5):653-64. doi: 10.1016/0090-6980(88)90140-2.
Transient incomplete cerebral ischemia (oligemia) has been obtained in rats by associating mild systemic hypotension with bilateral carotid artery occlusion for 60 min. Continuous i.v drug administration for 3 days, performed with Alzet osmotic minipumps so that to deliver 167 ng.kg-1.min-1 Iloprost, 5 ng.kg-1.min-1 ZK 96480 or their respective vehicle, started 1 hour post-oligemia. Both compounds which are stable prostacyclin analogues reduced the edematous reaction and the post-oligemic accumulation of calcium in the brain tissue but above all they improved, mainly ZK 96480, the learning capacity of injured animals. These results indicate that regarding its therapeutic effect toward early consequences of a transient cerebral oligemia, ZK 96480 has the same profile as Iloprost at a dose 20-fold lower. Thus, these data encourage further clinical studies, in ischemic stroke, in which PGI2 and Iloprost have been shown promising.
通过使轻度全身性低血压与双侧颈动脉闭塞60分钟相结合，在大鼠中诱导出短暂性不完全脑缺血（低灌注）。在低灌注后1小时开始，使用Alzet渗透微型泵连续静脉给药3天，以输送167 ng·kg-1·min-1的伊洛前列素、5 ng·kg-1·min-1的ZK 96480或它们各自的赋形剂。这两种稳定的前列环素类似物均减轻了脑组织中的水肿反应和低灌注后钙的蓄积，但最重要的是，它们改善了受伤动物的学习能力，ZK 96480的效果尤为明显。这些结果表明，就其对短暂性脑低灌注早期后果的治疗作用而言，ZK 96480在剂量低20倍的情况下与伊洛前列素具有相同的效果。因此，这些数据鼓励在缺血性中风中开展进一步的临床研究，在这类研究中，前列环素和伊洛前列素已显示出有前景的疗效。
