Navarro-Francés Concepción I, Arenas M Carmen
Facultad de Psicología, Departamento de Psicobiología, Universitat de València, Avda. Blasco Ibañez, 21, Valencia, 46010, Spain.
Facultad de Psicología, Departamento de Psicobiología, Universitat de València, Avda. Blasco Ibañez, 21, Valencia, 46010, Spain.
Behav Processes. 2014 Jun;105:6-14. doi: 10.1016/j.beproc.2014.02.009. Epub 2014 Feb 21.
The influence of anxiety on the effects of acute stress for the acquisition and retention of passive avoidance conditioned task was evaluated in male and female mice. Animals were categorized as high-, medium-, and low-anxiety according to their performance in the elevated plus-maze test. Subsequently, half of the mice in each group were exposed to an acute stressor and assayed in an aversive conditioning test two days later. Exposure to restraint stress before inhibitory avoidance conditioning had a differential impact on the conditioned response of males and females according to their trait anxiety. The acute stressor significantly altered the conditioned response of mice with a high-anxiety level. The long-term effect of the stressor varied for each sex; high-anxiety stressed males showed an enhanced conditioned response with respect to their controls, whereas high-anxiety stressed females presented an impaired performance. These results lead us to believe that the characterization of individuality is an important factor in understanding the interaction between stress and memory for each sex; the trait anxiety of our animals modulated the effects of stress on the conditioned response so that males and females performed in contrasting manners to the same environmental stimuli and experimental conditions.
在雄性和雌性小鼠中评估了焦虑对急性应激在被动回避条件任务的获得和保持方面影响。根据动物在高架十字迷宫试验中的表现，将它们分为高焦虑、中焦虑和低焦虑三类。随后，每组中的一半小鼠暴露于急性应激源，并在两天后进行厌恶条件试验。根据特质焦虑，在抑制性回避条件训练前暴露于束缚应激对雄性和雌性的条件反应有不同影响。急性应激源显著改变了高焦虑水平小鼠的条件反应。应激源的长期影响因性别而异；高焦虑应激雄性相对于其对照组表现出增强的条件反应，而高焦虑应激雌性表现出受损的表现。这些结果使我们相信，个体特征的表征是理解每种性别应激与记忆之间相互作用的一个重要因素；我们动物的特质焦虑调节了应激对条件反应的影响，使得雄性和雌性对相同的环境刺激和实验条件表现出相反的行为方式。
