自身免疫性脑炎伴面肩肱型肌阵挛发作的连续 FDG PET/CT
Serial FDG PET/CT in autoimmune encephalitis with faciobrachial dystonic seizures.
机构信息
From the *Hans Berger Department of Neurology, †Department of Nuclear Medicine, and ‡Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
出版信息
Clin Nucl Med. 2014 Oct;39(10):e436-8. doi: 10.1097/RLU.0000000000000372.
Autoimmune encephalitis (AE) is increasingly recognized as a nonparaneoplastic disorder with autoantibodies to neuronal proteins. Although MRI is frequently unremarkable, PET imaging might contribute to identification of affected brain regions in distinct AE. We report on serial FDG PET in a 72-year-old man with particular AE subtype, with potassium channel complex antibodies and prodromal stage with dystonic seizures. Serial FDG PET/CT revealed that besides limbic structures, basal ganglia are centrally involved and presumably play a key role in the generation of dystonic seizures.
自身免疫性脑炎（AE）作为一种非副肿瘤性疾病，其特征为神经元蛋白自身抗体阳性。尽管 MRI 通常无明显异常，但 PET 成像可能有助于确定不同 AE 的病变脑区。我们报告了一例具有特殊 AE 亚型（钾通道复合物抗体阳性，并有肌张力障碍性癫痫先兆期）的 72 岁男性患者的系列 FDG PET 检查结果。FDG PET/CT 连续检查显示，除了边缘系统结构外，基底节也存在中枢受累，可能在肌张力障碍性癫痫的发生中起关键作用。
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