DiSSal Section of Dermatology AOU San Martino‑IST Genoa, IRCCS University of Genoa, Genoa, Italy -
G Ital Dermatol Venereol. 2014 Feb;149(1):79-81.
Hair loss is commonly seen in autoimmune diseases. In pemphigus, although scalp involvement is common, hair loss is rarely reported. In classical bullous pemphigoid, alopecia is not reported while it is described in the Brusting-Perry variant of bullous pemphigoid and in epidermolysis bullosa acquisita. In these two diseases alopecia is cicatricial. In connective tissue diseases, in lupus erythematosus (LE) hair loss is frequent; in particular in LE there are two types of alopecia: non scarring and scarring alopecia. The non scarring form is a finding of acute systemic LE and the scarring form develops when a typical discoid lesion is located on the scalp. In dermatomyositis alopecia is usually non scarring and generalized. In scleroderma, alopecia is associated with en coupe de sabre morphea.
脱发在自身免疫性疾病中很常见。在天疱疮中，尽管头皮受累很常见，但很少报道脱发。在经典大疱性类天疱疮中，脱发不被报道，而在大疱性类天疱疮的 Brusting-Perry 变异型和获得性大疱性表皮松解症中则有描述。在这两种疾病中，脱发是瘢痕性的。在结缔组织疾病中，红斑狼疮（LE）脱发很常见；特别是在 LE 中，有两种类型的脱发：非瘢痕性和瘢痕性脱发。非瘢痕性脱发是急性全身性 LE 的表现，而当典型盘状皮损位于头皮上时，则会出现瘢痕性脱发。在皮肌炎中，脱发通常是非瘢痕性和全身性的。在硬皮病中，脱发与盔甲状硬斑病有关。
