el Arabi I, Ghafouri H, Serebour F, Saggaff H, Acquaye J
Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Ann Trop Paediatr. 1988 Jun;8(2):116-21. doi: 10.1080/02724936.1988.11748552.
Recurrent and often serious infections are common in sickle cell anaemia. The predisposing causes are multiple, and immune abnormalities are frequently blamed. In this study, immune complexes, lymphocyte subpopulations, immunoglobulins and complement were determined in 40 Arabs with sickle cell anaemia to ascertain some aspects of their immunological profile. Immunoglobulins were found to be either normal or high, C3 and C4 values mostly clustered at the lower level of normal with a few values below normal, and some patients had low T4/T8 lymphocyte ratios. The results are discussed and compared with previous studies.
复发性且常为严重的感染在镰状细胞贫血中很常见。易感因素是多方面的，免疫异常常被归咎于此。在本研究中，对40名患有镰状细胞贫血的阿拉伯人测定了免疫复合物、淋巴细胞亚群、免疫球蛋白和补体，以确定其免疫特征的某些方面。发现免疫球蛋白正常或升高，C3和C4值大多聚集在正常范围的下限，少数值低于正常，一些患者的T4/T8淋巴细胞比值较低。对结果进行了讨论并与先前的研究进行了比较。
