a Laboratory of Infection and Prevention, Department of Biological Responses , Institute for Virus Research, Kyoto University , Kyoto , Japan.
Biotechnol Genet Eng Rev. 2013;29:49-60. doi: 10.1080/02648725.2013.801236.
Cytokines are critical mediators of inflammation and host defense. Cytokine production is regulated during transcription and post-transcription. Post-transcriptional regulation modifies mRNA stability and translation, allowing for the rapid and flexible control of gene expression, which is important for coordinating the initiation and resolution of inflammation. We review here a variety of post-transcriptional control mechanisms that regulate inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
细胞因子是炎症和宿主防御的关键介质。细胞因子的产生在转录和转录后受到调节。转录后调节改变 mRNA 的稳定性和翻译，从而能够快速灵活地控制基因表达，这对于协调炎症的起始和解决非常重要。我们在这里回顾了各种调节炎症的转录后控制机制，并讨论了这些机制如何整合以协调这一基本过程。
