慢性阻塞性肺疾病发生过程中蛋白质表达的异常转录后调控。
Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease.
机构信息
Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.
Department of Medical Laboratory Technology, Applied Medical Science, Taibah University, Universities Road, Medina P.O. Box 344, Saudi Arabia.
出版信息
Int J Mol Sci. 2021 Nov 4;22(21):11963. doi: 10.3390/ijms222111963.
Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular processes, including the post-transcriptional regulation of mRNAs. The identification of RNA-binding proteins (RBPs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) as main factors engaged in the regulation of RNA biology opens the door to understanding their role in coordinating physiological cellular processes. Dysregulation of post-transcriptional regulation by foreign particles in CS may lead to the development of diseases such as COPD. Here we review current knowledge about post-transcriptional events that may be involved in the pathogenesis of COPD.
慢性阻塞性肺疾病（COPD）是一种无法治愈且普遍存在的呼吸系统疾病，其特征是慢性炎症和肺气肿。COPD 主要由香烟烟雾（CS）引起。CS 改变了许多细胞过程，包括 mRNA 的转录后调控。RNA 结合蛋白（RBPs）、微小 RNA（miRNAs）和长非编码 RNA（lncRNAs）作为参与调节 RNA 生物学的主要因素的鉴定，为了解它们在协调生理细胞过程中的作用开辟了道路。CS 中外来颗粒对转录后调控的失调可能导致 COPD 等疾病的发展。在这里，我们回顾了可能参与 COPD 发病机制的转录后事件的最新知识。
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