Ishida-Yamamoto A, Senba E, Tohyama M
Department of Anatomy II, Osaka University Medical School, Japan.
Brain Res. 1988 Jun 21;453(1-2):362-6. doi: 10.1016/0006-8993(88)90179-5.
The present study demonstrates that about 15% of the Meissner's corpuscles (MCs) of the rat glabrous skin of the feet contain one to two fibers immunoreactive for calcitonin gene-related peptide (CGRP), and that these fibers originate from the dorsal root ganglion. Double immunofluorescent cytochemical investigation has revealed that almost all the CGRP-immunoreactive (CGRPI) fibers in the MCs were immunoreactive for substance P. Subsequent immunoelectron microscopic analysis has demonstrated that the CGRPI fibers in the MCs are unmyelinated. In the course of passage through the MCs, no synaptic contact between the CGRPI fibers and underlying cells or non-CGRPI fibers was found.
本研究表明，大鼠足部无毛皮肤的迈斯纳小体（MCs）中约15%含有一至两条对降钙素基因相关肽（CGRP）呈免疫反应的纤维，且这些纤维起源于背根神经节。双重免疫荧光细胞化学研究显示，MCs中几乎所有对CGRP呈免疫反应（CGRPI）的纤维对P物质也呈免疫反应。随后的免疫电子显微镜分析表明，MCs中的CGRPI纤维是无髓鞘的。在穿过MCs的过程中，未发现CGRPI纤维与下层细胞或非CGRPI纤维之间有突触联系。
