Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
J Anat. 2022 Nov;241(5):1186-1210. doi: 10.1111/joa.13544. Epub 2021 Sep 15.
Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compartments include specialised sensory endings in the skin, the nodes of Ranvier in myelinated axons, the cell soma and their central terminals in the spinal cord. In this review, we will highlight the importance of these compartments to primary afferent function, describe how these structures are compromised following nerve damage and how this relates to neuropathic pain.
初级感觉神经元是一个能够对无害和有害刺激做出反应的异质细胞群体。像大多数神经元一样，它们高度分隔，使它们能够检测、传递和传输感觉信息。这些隔室包括皮肤中的特殊感觉末梢、有髓轴突中的郎飞结、细胞体及其在脊髓中的中枢末端。在这篇综述中，我们将强调这些隔室对初级传入功能的重要性，描述这些结构在神经损伤后如何受到损害，以及这与神经病理性疼痛的关系。
