Xu Chuan, Lv Peng-Hua, Huang Xin-En, Wang Shu-Xiang, Sun Ling, Wang Fu-An, Wang Li-Fu
Department of Interventional Radiology, Subei People Hospital of Jiangsu Province, Clinical Hospital of Yangzhou University, Yangzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(2):703-6. doi: 10.7314/apjcp.2014.15.2.703.
To evaluate the safety and efficacy of sequential transcatheter arterial chemoembolization (TACE )and portal vein embolization (PVE) before major hepatectomy for patients with hepatocellur carcinoma (HCC).
In this retrospective case-control study, data were collected from patients who underwent sequential TACE and PVE prior to major hemihepactectomy. Liver volumes were measured by computed tomography volumetry before TACE, and preoperation to assess degree of future remnant liver (FRL) hypertrophy and to check whether intro- or extrohepatic metastasis existed. Liver function was monitored by biochemistry after TACE, prior to and after major hepatectomy.
Mean average FRL volume increased 32.3-71.4% (mean 55.4%) compared with preoperative FRL volume. After TACE, liver enzymes were elevated, but returned to normal in four weeks. During PVE and resection, no patient had intro- or extrohepatic metastasis.
Sequential TACE and PVE is an effective method to improve resection opportunity, expand the scope of surgical resection, and greatly reduce postoperative intra- and extrahepatic metastasis.
评估经导管动脉化疗栓塞术（TACE）序贯门静脉栓塞术（PVE）对肝细胞癌（HCC）患者在大肝切除术前的安全性和有效性。
在这项回顾性病例对照研究中，收集了在大肝半肝切除术前接受序贯TACE和PVE的患者的数据。在TACE前通过计算机断层扫描容积测量法测量肝脏体积，并在术前评估未来残余肝（FRL）肥大程度以及检查是否存在肝内或肝外转移。在TACE后、大肝切除术前和术后通过生化指标监测肝功能。
与术前FRL体积相比，平均FRL体积增加了32.3%-71.4%（平均55.4%）。TACE后，肝酶升高，但在四周内恢复正常。在PVE和切除过程中，没有患者发生肝内或肝外转移。
序贯TACE和PVE是一种有效的方法，可提高切除机会，扩大手术切除范围，并大大降低术后肝内和肝外转移。
