Peng Dong, Zhang Bin, Yuan Chao, Tong Yue, Zhang Wei
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Surg. 2022 Oct 20;9:1004064. doi: 10.3389/fsurg.2022.1004064. eCollection 2022.
Gastric transcatheter chemoembolization (GTC) is an interventional minimal invasive method, which has never been mentioned in the previous literature for advanced gastric cancer with obstruction. The purpose of this study was to evaluate its safety and efficacy in treating advanced gastric cancer with obstruction.
Advanced gastric cancer patients with obstruction who underwent GTC were retrospectively analysed from June 2017 to January 2020. Baseline information, peri-intervention data, and post-intervention follow-up information were collected. Clinical data obtained before and after the GTC were compared, and the survival of all patients was analysed.
Forty-Two patients were included in this study. 42 (100%) patients achieved technical success, and 22 (52.4%) achieved clinical success. The median time of the GTC was 83 (30.0-180.0) minutes, and the median time of hospitalization after GTC was 3 (1-6) days. One patient experienced abdominal pain during and after GTC. Twenty (47.6%) of the 42 patients underwent gastrectomy after intervention. The pre-intervention gastric outlet obstruction scoring system (GOOSS) was 1 (0-1) and the post-intervention GOOSS was 2 (0-3) ( = 0.000 < 0.05). The median follow-up time was 9.5 (3-35) months, and the overall survival time was 14 months. In the univariate survival analysis, a significant difference was observed between patients who did or did not undergo radical gastrectomy after GTC ( = 0.014 < 0.05).
GTC is a safe and effective treatment, and furthermore, it could be an alternative method in treating advanced gastric cancer with obstruction.
胃动脉化疗栓塞术（GTC）是一种介入性微创方法，既往文献中从未提及用于治疗伴有梗阻的晚期胃癌。本研究的目的是评估其治疗伴有梗阻的晚期胃癌的安全性和有效性。
回顾性分析2017年6月至2020年1月期间接受GTC治疗的伴有梗阻的晚期胃癌患者。收集基线信息、干预期间数据和干预后随访信息。比较GTC前后获得的临床数据，并分析所有患者的生存情况。
本研究纳入42例患者。42例（100%）患者技术成功，22例（52.4%）患者临床成功。GTC的中位时间为83（30.0 - 180.0）分钟，GTC后住院中位时间为3（1 - 6）天。1例患者在GTC期间及之后出现腹痛。42例患者中有20例（47.6%）在干预后接受了胃切除术。干预前胃出口梗阻评分系统（GOOSS）为1（0 - 1），干预后GOOSS为2（0 - 3）（= 0.000 < 0.05）。中位随访时间为9.5（3 - 35）个月，总生存时间为14个月。在单因素生存分析中，GTC后接受或未接受根治性胃切除术的患者之间存在显著差异（= 0.014 < 0.05）。
GTC是一种安全有效的治疗方法，此外，它可能是治疗伴有梗阻的晚期胃癌的一种替代方法。
