Klysik Michal, Garg Samita, Pokharel Sajal, Meier Jeffery, Patel Nayana, Garg Kavita
1 Department of Radiology, University of Colorado Denver School of Medicine , Aurora, Colorado.
Diabetes Technol Ther. 2014 Apr;16(4):266-74. doi: 10.1089/dia.2014.0026. Epub 2014 Feb 25.
A growing body of evidence supports a connection among diabetes (predominantly type 2), obesity, and cancer. Multiple meta-analyses of epidemiological data show that people with diabetes are at increased risk of developing a variety of different cancers and suffer from an increased rate of perioperative complications and cancer mortality. Computed tomography (CT) has played an important role in diagnosis and staging of cancer. Positron emission tomography is complementary to CT in the diagnosis, staging, and evaluation of treatment response for many types of cancer. Because of generally poor clinical outcome of cancers when they are detected in late stages, more research is now focused on stratifying risk to allow personalized screening of at-risk patients and cancer detection at an earlier stage. In this review, we summarize basic noninvasive imaging techniques currently in use to detect cancer with emphasis on the challenges of imaging for early cancer detection in obese patients with diabetes.
越来越多的证据支持糖尿病（主要是2型）、肥胖症和癌症之间存在关联。多项流行病学数据的荟萃分析表明，糖尿病患者患多种不同癌症的风险增加，围手术期并发症发生率和癌症死亡率也更高。计算机断层扫描（CT）在癌症的诊断和分期中发挥了重要作用。正电子发射断层扫描在多种癌症的诊断、分期和治疗反应评估方面与CT互为补充。由于癌症在晚期被检测到时临床结局通常较差，现在更多的研究集中在风险分层上，以便对高危患者进行个性化筛查并在更早阶段检测出癌症。在本综述中，我们总结了目前用于检测癌症的基本非侵入性成像技术，重点介绍了糖尿病肥胖患者早期癌症检测成像面临的挑战。
