Chockalingam Priya, Wilde Arthur A
Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.
Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands; Princess Al-Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Indian Heart J. 2014 Jan-Feb;66 Suppl 1(Suppl 1):S49-57. doi: 10.1016/j.ihj.2013.11.008. Epub 2013 Dec 17.
Inherited primary arrhythmias, namely congenital long QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia, account for a significant proportion of sudden cardiac deaths in young and apparently healthy individuals. Genetic testing plays an integral role in the diagnosis, risk-stratification and treatment of probands and family members. It is increasingly obvious that collaborative efforts are required to understand and manage these relatively rare but potentially lethal diseases. This article aims to update readers on the recent developments in our knowledge of inherited arrhythmias and to lay the foundation for a national synergistic effort to characterize them in the Indian population.
遗传性原发性心律失常,即先天性长QT综合征、Brugada综合征和儿茶酚胺能多形性室性心动过速,在年轻且看似健康的个体中占心脏性猝死的很大比例。基因检测在先证者及其家庭成员的诊断、危险分层和治疗中起着不可或缺的作用。越来越明显的是,需要共同努力来理解和管理这些相对罕见但可能致命的疾病。本文旨在向读者介绍我们在遗传性心律失常知识方面的最新进展,并为在印度人群中对其进行特征描述的全国性协同努力奠定基础。