Sieber Cornel C
Friedrich-Alexander Universität Erlangen-Nürnberg und Klinik für Allgemeine Innere Medizin und Geriatrie, Krankenhaus Barmherzige Brüder, Regensburg.
Ther Umsch. 2014 Mar;71(3):171-6. doi: 10.1024/0040-5930/a000499.
The term sarcopenia stands for the age-related loss of muscle mass and is pahophysiologically closely linked to the "frailty syndrome". The search for sarcopenia - the combination of both a muscle loss and a reduced muscle function or strength - is nowadays part of the comprehensive geriatric assessment in Geriatric Medicine. From a pahophysiological point of view, different factors are involved as in all geriatric snydromes, but a low-grade inflammatory state is a cornerstone in all of them. Differentiation to cachexia is important, as the latter is not as amenable to treatment strategies. Many questions including the international full acceptance of the defintition of sarcopenia remain open. A good example is sarcoepnic obesity, a quantitatively fast increasing challenge in elderly persons.
肌肉减少症一词代表与年龄相关的肌肉量流失，在病理生理学上与“衰弱综合征”密切相关。如今，寻找肌肉减少症（肌肉量流失与肌肉功能或力量下降并存）已成为老年医学综合老年评估的一部分。从病理生理学角度来看，与所有老年综合征一样，涉及不同因素，但低度炎症状态是所有这些因素的基石。与恶病质进行区分很重要，因为后者对治疗策略的反应不同。包括国际上对肌肉减少症定义的完全接受在内的许多问题仍未解决。一个很好的例子是肌少症性肥胖，这在老年人中是一个数量上快速增加的挑战。
