Al-Jamal Rana'a T, Kivelä Tero
Ocular Oncology Service, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland.
Ocular Oncology Service, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland.
J AAPOS. 2014 Feb;18(1):61-6. doi: 10.1016/j.jaapos.2013.11.006.
To characterize uveal melanoma (UM) among children and young adults in a high-risk region for this cancer.
The medical records of consecutive patients <25 years of age with UM treated from 1962 to 2009 were retrospectively reviewed. The following data were collected: sex, tumor location and size, tumor node metastasis (TNM) stage, vision, and survival. We compared data with five previous series reporting 70 matching patients and combined them for meta-analysis of survival.
Of 1,185 UM patients, 18 were eligible. UM frequency in patients <25 years of age was 1.3%; in those ≤20 years of age, 0.6%. Median follow-up time was longer than in the previous series combined (11.6 vs 5.4 years). Females outnumbered males 2:1. Median tumor thickness was higher in our series (8 vs 5 mm) and increased with age. Median tumor diameter was similar to previous series (12 mm). Of our patients, 83% were stage II; 17%, stage III. In previous series, 26% were stage I; 64%, stage II; and 10%, stage III. Survival was 76% at 5 and 10 years, compared to 98% in previous series. By meta-analysis, mortality increased with stage, age > 17 years, female sex, and if the ciliary body was involved.
Tumor stage was higher than in other regions. Age >17 years, female sex, and tumor stage adversely influenced survival among patients <25 years of age with UM.
在该癌症的高风险地区对儿童和青年的葡萄膜黑色素瘤（UM）进行特征描述。
回顾性分析1962年至2009年期间接受治疗的连续25岁以下UM患者的病历。收集以下数据：性别、肿瘤位置和大小、肿瘤淋巴结转移（TNM）分期、视力和生存情况。我们将数据与之前报道70例匹配患者的五个系列进行比较，并将它们合并以进行生存情况的荟萃分析。
在1185例UM患者中，18例符合条件。25岁以下患者中UM的发生率为1.3%；20岁及以下患者中为0.6%。中位随访时间比之前系列合并后的时间更长（11.6年对5.4年）。女性人数是男性的两倍。我们系列中的肿瘤中位厚度更高（8毫米对5毫米），且随年龄增加。肿瘤中位直径与之前系列相似（12毫米）。我们的患者中，83%为II期；17%为III期。在之前的系列中，26%为I期；64%为II期；10%为III期。5年和10年生存率为76%，而之前系列为98%。通过荟萃分析，死亡率随分期、年龄>17岁、女性以及睫状体受累而增加。
肿瘤分期高于其他地区。年龄>17岁、女性和肿瘤分期对25岁以下UM患者的生存有不利影响。
