血清尿酸水平与10至15岁中国儿童及青少年的高血压有关。
Serum uric acid levels are associated with high blood pressure in Chinese children and adolescents aged 10-15 years.
作者信息
Pan Shuo, He Chun-Hui, Ma Yi-Tong, Yang Yi-Ning, Ma Xiang, Fu Zhen-Yan, Li Xiao-Mei, Xie Xiang, Yu Zi-Xiang, Chen You, Liu Fen, Chen Bang-Dang, Nakayama Tomohiro
机构信息
aDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University bXinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, People's Republic of China cDivision of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan *Shuo Pan and Chun-Hui He contribute equally to the writing of the article.
出版信息
J Hypertens. 2014 May;32(5):998-1003; discussion 1004. doi: 10.1097/HJH.0000000000000126.
OBJECTIVE
The present study examined the association between uric acid levels and high blood pressure in a multiethnic study of Chinese children and adolescents.
METHODS
The participants were divided into four different groups according to the uric acid quartiles. Three logistic regression models were conducted to investigate the relationship between the high blood pressure and uric acid levels. Model 1 adjusted age, sex and ethnicity. Model 2 adjusted age, sex, ethnicity, total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, estimated glomerular filtration rate, fasting glucose and waist circumference. Model 3 adjusted all the confounding factors in model 2 except the waist circumference and BMI. The concentrations of uric acid in high blood pressure participants and normotensive participants were compared with or without adjustment for confounding factors.
RESULTS
A total of 3778 participants aged 10-15 years from the Xinjiang Congenital Heart Disease Survey were included in the present study. The percentages of the high blood pressure in the four different uric acid quartiles were 7.4, 8.6, 9.6 and 11.8%, respectively. In model 1, 2 and 3 of the logistic regression, the participants in the third and fourth uric acid quartiles had significantly higher chance of suffering the high blood pressure when compared with the participants in the first uric acid quartile [odds ratio 1.608, 1.587, 1.597, P = 0.005, 0.015, 0.015, respectively, between participants in the first quartile and the third quartile; odds ratio 1.981, 1.945, 1.810, P = 0.001, 0.002, 0.007, respectively, between participants in the first quartile and the fourth quartile). The concentrations of serum uric acid were 220.7 μmol/l in high blood pressure participants and 204.1 μmol/l in normotensive participants (P = 0.024). After adjustment for confounding factors, the concentrations of serum uric acid were 219.7 vs. 204.5 μmol/l in one model (P < 0.001) and 219.3 vs. 204.5 μmol/l in the other model (P < 0.001).
CONCLUSIONS
Among Chinese children and adolescents, increasing levels of serum uric acid are associated with high blood pressure.
目的
本研究在一项针对中国儿童和青少年的多民族研究中，考察尿酸水平与高血压之间的关联。
方法
参与者根据尿酸四分位数被分为四个不同组。进行了三个逻辑回归模型以研究高血压与尿酸水平之间的关系。模型1对年龄、性别和种族进行了调整。模型2对年龄、性别、种族、总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯、估计肾小球滤过率、空腹血糖和腰围进行了调整。模型3对模型2中的所有混杂因素进行了调整，但未包括腰围和体重指数。对高血压参与者和血压正常参与者的尿酸浓度进行了比较，比较时对混杂因素进行或未进行调整。
结果
本研究纳入了来自新疆先天性心脏病调查的3778名10至15岁的参与者。四个不同尿酸四分位数中高血压的百分比分别为7.4%、8.6%、9.6%和11.8%。在逻辑回归的模型1、2和3中，与第一尿酸四分位数的参与者相比，第三和第四尿酸四分位数的参与者患高血压的几率显著更高[第一四分位数与第三四分位数参与者之间的比值比分别为1.608、1.587、1.597，P = 0.005、0.015、0.015；第一四分位数与第四四分位数参与者之间的比值比分别为1.981、1.945、1.810，P = 0.001、0.002、0.007]。高血压参与者的血清尿酸浓度为220.7μmol/l，血压正常参与者的血清尿酸浓度为204.1μmol/l（P = 0.024）。在对混杂因素进行调整后，在一个模型中血清尿酸浓度为219.7 vs. 204.5μmol/l（P < 0.001），在另一个模型中为219.3 vs. 204.5μmol/l（P < 0.001）。
结论
在中国儿童和青少年中，血清尿酸水平升高与高血压相关。
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