骨髓增生异常综合征：与FAB分类相关的形态学特征分析

Myelodysplastic syndromes: analysis of morphological features related to the FAB-classification.

作者信息

van der Weide M, Sizoo W, Krefft J, Langenhuijsen M M

机构信息

Department of Haematology, Free University, Amsterdam, The Netherlands.

出版信息

Eur J Haematol. 1988 Jul;41(1):58-61. doi: 10.1111/j.1600-0609.1988.tb00869.x.

DOI:10.1111/j.1600-0609.1988.tb00869.x

PMID:2456946

Abstract

In a retrospective study of 96 patients with a myelodysplastic syndrome, the reproducibility of the French-American-British (FAB) classification was determined. Morphological abnormalities in peripheral blood and bone marrow were studied. Slides were reviewed by 3 examiners. All 3 observers agreed on morphological classification in 61% of cases, pairs of 2 in 64, 76 and 76%. The final diagnosis was refractory anaemia (RA) in 7 patients, acquired sideroblastic anaemia (AISA) in 2, chronic myelomonocytic leukaemia (CMML) in 31, refractory anaemia with excess of blasts (RAEB) in 34 and RAEB in transformation (RAEB-t) in 22. Dyserythropoiesis, dysgranulopoiesis and dysmegakaryopoiesis were found in all FAB subgroups. Dyserythropoiesis was significantly more frequently encountered in RAEB than in RAEB-t and CMML.

摘要

在一项对96例骨髓增生异常综合征患者的回顾性研究中，确定了法美英（FAB）分类法的可重复性。研究了外周血和骨髓中的形态学异常。玻片由3名检查人员进行复查。所有3名观察者在61%的病例中对形态学分类达成一致，2名观察者分别在64%、76%和76%的病例中达成一致。最终诊断为7例难治性贫血（RA）、2例获得性铁粒幼细胞贫血（AISA）、31例慢性粒-单核细胞白血病（CMML）、34例伴有过多原始细胞的难治性贫血（RAEB）和22例转化中的RAEB（RAEB-t）。在所有FAB亚组中均发现了红细胞生成异常、粒细胞生成异常和巨核细胞生成异常。红细胞生成异常在RAEB中比在RAEB-t和CMML中更常见。