Korhonen T K, Haahtela K, Pirkola A, Parkkinen J
Department of General Microbiology, University of Helsinki, Finland.
FEBS Lett. 1988 Aug 15;236(1):163-6. doi: 10.1016/0014-5793(88)80307-7.
A strain of the phytopathogenic bacterial species, Erwinia rhapontici, was found to cause hemagglutination of human erythrocytes that was specifically inhibited by beta-galactosides. Of the monosaccharides tested, N-acetyl galactosamine and galactose efficiently inhibited the hemagglutination. The most potent inhibitor identified was Ga1 beta 1-4GlcNAc that was 30-100-fold more potent than Ga1 beta 1-3GlcNac or Ga1 beta 1-3GalNAc. Fetuin had no effect on the hemagglutination whereas asialofetuin was inhibitory. No blood group specificity was found for the hemagglutinin. These findings indicate that the E. rhapontici strain possesses a novel bacterial cell-binding activity with specificity for terminal N-acetyllactosamine residues.
人们发现，一种植物致病细菌——莱茵衣藻欧文氏菌（Erwinia rhapontici）的菌株能引起人红细胞的血凝反应，而这种反应会被β-半乳糖苷特异性抑制。在所测试的单糖中，N-乙酰半乳糖胺和半乳糖能有效抑制血凝反应。已鉴定出的最有效的抑制剂是Galβ1-4GlcNAc，其效力比Galβ1-3GlcNac或Galβ1-3GalNAc强30至100倍。胎球蛋白对血凝反应没有影响，而脱唾液酸胎球蛋白具有抑制作用。未发现该血凝素具有血型特异性。这些发现表明，莱茵衣藻欧文氏菌菌株具有一种新型的细菌细胞结合活性，对末端N-乙酰乳糖胺残基具有特异性。
