Bauwens Matthias, Pooters Ivo, van der Pol Jochen, Mottaghy Felix M, van Kroonenburgh Marinus
aDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+ bNUTRIM, Maastricht University, Maastricht, The Netherlands cDepartment of Nuclear Medicine, UniKlinikum RWTH Aachen, Aachen, Germany.
Nucl Med Commun. 2014 Apr;35(4):433-7. doi: 10.1097/MNM.0000000000000073.
(99m)Tc-dimercaptosuccinic acid [DMSA(III)] and colloidal human serum albumin ((99m)Tc-nanocolloid) are widely used radiopharmaceuticals. Recently, in our institution we encountered image quality problems in DMSA scans after changing the brand of syringes we were using, which triggered us to look into the adsorption properties of syringes from different brands for (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid. We also describe a clinical case in which adsorption of (99m)Tc-DMSA(III) caused inferior imaging quality. DMSA and nanocolloid were labeled with (99m)Tc following manufacturer guidelines. After synthesis, syringes with (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid were stored for 15, 30, 60, and 120 min. We evaluated Luer Lock syringes manufactured by different brands such as Artsana, Henke-Sass-Wolf, B. Braun Medical N.V., CODAN Medizinische Geräte GmbH & Co KG, Becton Dickinson and Company, and Terumo Europe. Adsorption of (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid was acceptably low for all syringes (<13%), except for two brands with (99m)Tc-DMSA(III) adsorption rates of 36 and 30%, respectively, and for one brand with a (99m)Tc-nanocolloid adsorption rate of 27%. Adsorption of (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid reaches critical levels in syringes produced by two brands, potentially causing poor image quality--for example, in DMSA scans using pediatric radiopharmaceutical doses. It is advised to check the compatibility of any radiopharmaceutical with syringes as an integral part of the quality assurance program.
锝-99m二巯基丁二酸[DMSA(III)]和人血清白蛋白胶体（锝-99m纳米胶体）是广泛使用的放射性药物。最近，在我们机构，更换所用注射器品牌后，我们在DMSA扫描中遇到了图像质量问题，这促使我们研究不同品牌注射器对锝-99m-DMSA(III)和锝-99m纳米胶体的吸附特性。我们还描述了一个临床病例，其中锝-99m-DMSA(III)的吸附导致成像质量较差。DMSA和纳米胶体按照制造商指南用锝-99m进行标记。合成后，装有锝-99m-DMSA(III)和锝-99m纳米胶体的注射器分别储存15、30、60和120分钟。我们评估了不同品牌生产的鲁尔锁注射器，如阿萨纳、亨克-萨斯-沃尔夫、贝朗医疗有限公司、科丹医疗器械股份公司、碧迪医疗器械公司和泰尔茂欧洲公司。除了两个品牌的锝-99m-DMSA(III)吸附率分别为36%和30%，以及一个品牌的锝-99m纳米胶体吸附率为27%外，所有注射器对锝-99m-DMSA(III)和锝-99m纳米胶体的吸附率都低至可接受水平（<13%）。两个品牌生产的注射器中，锝-99m-DMSA(III)和锝-99m纳米胶体的吸附达到临界水平，可能导致图像质量不佳——例如，在使用儿科放射性药物剂量的DMSA扫描中。建议将检查任何放射性药物与注射器的兼容性作为质量保证计划的一个组成部分。
