Jansson B A, Göransson M B, Agren B N
Hospital Pharmacy, Huddinge University Hospital, Sweden.
J Nucl Med Technol. 1998 Sep;26(3):196-9.
The purpose of this study was to determine the adsorption behavior of some widely used, commercially available 99mTc radiopharmaceuticals onto different types of plastic syringes.
Kits were reconstituted with 99mTc-pertechnetate diluted with 0.9% saline to produce maximum radioactive concentrations, as stated by the manufacturers. Aliquots of the solutions were transferred to four different brands of 2-ml syringes. The activity in the syringes was measured before and after injections or simulated injections. The amount adsorbed to the plastic syringe barrel and plunger before and after washout also was measured at different time intervals. Comparisons between products from different manufacturers were made for 99mTc succimer (DMSA) and 99mTc macroaggregated albumin (MAA).
Some 99mTC preparations undergo significant adsorption to plastic syringes. Adsorption differs considerably between products from different manufacturers. There was significantly higher residual activity in some types of syringes. In some cases the residual was as high as 40%-50% of the initial activity, and most of the adsorption occurred within 15 min of filling the syringe.
The data suggest that the extent of adsorption depends on pharmaceutical excipients in the kits and/or the type of syringe used. When inappropriate syringes are used, the reduction in the administered activity may result in poor-quality images. Therefore, the compatibility between radiopharmaceutical and syringe should be investigated under normal conditions of preparation and use every time a new brand of syringe or a new radiopharmaceutical comes into use in diagnostic nuclear medicine.
本研究旨在确定一些广泛使用的市售99mTc放射性药物在不同类型塑料注射器上的吸附行为。
按照制造商的说明，用0.9%生理盐水稀释的高锝[99mTc]酸盐重构试剂盒，以产生最大放射性浓度。将溶液的等分试样转移到四个不同品牌的2毫升注射器中。在注射或模拟注射前后测量注射器中的活性。还在不同时间间隔测量冲洗前后吸附到塑料注射器针筒和活塞上的量。对不同制造商生产的99mTc二巯基丁二酸（DMSA）和99mTc大颗粒白蛋白（MAA）产品进行比较。
一些99mTc制剂会大量吸附到塑料注射器上。不同制造商的产品之间吸附情况差异很大。某些类型的注射器中残留活性明显更高。在某些情况下，残留量高达初始活性的40%-50%，且大部分吸附在注射器灌装后15分钟内发生。
数据表明，吸附程度取决于试剂盒中的药物赋形剂和/或所用注射器的类型。使用不合适的注射器时，给药活性的降低可能导致图像质量不佳。因此，每当诊断核医学中使用新品牌的注射器或新的放射性药物时，都应在正常制备和使用条件下研究放射性药物与注射器之间的兼容性。
