Succony L, Janes S M
From the Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK.
From the Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK
QJM. 2014 Aug;107(8):607-12. doi: 10.1093/qjmed/hcu040. Epub 2014 Feb 24.
Lung cancer is the biggest cancer killer in the UK and despite recent therapeutic advances there is a desperate need for new therapies to improve outcomes from this devastating disease. Through defining the spatial location of the airway epithelial stem or progenitor cell populations and their mechanisms of maintenance and repair of the epithelium it is becoming clear that these populations are situated at areas corresponding to those involved in lung cancer initiation. We explore the evidence for stem cells being the cancer initiator cell and for a 'lung cancer stem cell' within tumours that may be the cause of resistance to current therapies.
肺癌是英国最大的癌症杀手，尽管最近在治疗方面取得了进展，但仍迫切需要新的疗法来改善这种毁灭性疾病的治疗效果。通过确定气道上皮干细胞或祖细胞群体的空间位置及其维持和修复上皮的机制，越来越清楚的是，这些群体位于与肺癌起始相关的区域。我们探讨了干细胞作为癌症起始细胞的证据，以及肿瘤内可能是导致对当前疗法产生抗性原因的“肺癌干细胞”的证据。
