Funakoshi Yasunobu, Takeuchi Yukiyasu, Maeda Hajime
Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Toyonaka, Osaka, Japan.
Asian Cardiovasc Thorac Ann. 2013 Aug;21(4):482-4. doi: 10.1177/0218492312462834. Epub 2013 Jul 9.
A 69-year-old Japanese woman who had never smoked had lung adenocarcinoma harboring epidermal growth factor receptor mutation. After 8 months of gefitinib treatment, salvage pneumonectomy was performed. Microscopic examination showed that non-responsive adenocarcinoma remained although necrosis was prominent. Postoperatively, the patient developed empyema that was successfully managed. The postoperative empyema after treatment with gefitinib should be noted, as well as the finding that residual viable tumor cells remained even after the dramatic radiographic response.
一名69岁从不吸烟的日本女性患有携带表皮生长因子受体突变的肺腺癌。吉非替尼治疗8个月后，进行了挽救性肺切除术。显微镜检查显示，尽管坏死明显，但仍有未缓解的腺癌残留。术后，患者发生脓胸，经成功治疗。应注意吉非替尼治疗后的术后脓胸，以及即使在影像学上有显著反应后仍有残留存活肿瘤细胞的情况。
