Lin Chen, Song Wei, Bi Xinyu, Zhao Jianjun, Huang Zhen, Li Zhiyu, Zhou Jianguo, Cai Jianqiang, Zhao Hong
Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Onco Targets Ther. 2014 Feb 18;7:315-24. doi: 10.2147/OTT.S57023. eCollection 2014.
The human AT-rich interaction domain (ARID) family contains seven subfamilies and 15 members characterized by having an ARID. Members of the ARID family have the ability to regulate transcription and are involved in cell differentiation and proliferation. Accumulating evidence suggests that ARID family members are involved in cancer-related signaling pathways, highly mutated or differentially expressed in tumor tissues, and act as predictive factors for cancer prognosis or therapeutic outcome. Here we review the molecular biology and clinical studies concerned with the role played by the ARID family in cancer. This may contribute to our understanding of the initiation and progression of cancer from a novel point of view, as well as providing potential targets for cancer therapy.
人类富含AT的相互作用结构域（ARID）家族包含七个亚家族和15个成员，其特征是具有一个ARID。ARID家族成员具有调节转录的能力，并参与细胞分化和增殖。越来越多的证据表明，ARID家族成员参与癌症相关信号通路，在肿瘤组织中高度突变或差异表达，并作为癌症预后或治疗结果的预测因子。在此，我们综述了有关ARID家族在癌症中作用的分子生物学和临床研究。这可能有助于我们从新的角度理解癌症的发生和发展，同时也为癌症治疗提供潜在靶点。
