Bansal Rinkesh Kumar, Tyagi Pankaj, Sharma Praveen, Singla Vikas, Arora Veronica, Bansal Naresh, Kumar Ashish, Arora Anil
Department of Gastroenterology & Hepatology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India.
J Med Case Rep. 2014 Feb 26;8:74. doi: 10.1186/1752-1947-8-74.
Vitamin D is increasingly recognized to have several beneficial effects. Vitamin D deficiency is widely prevalent. Physicians often treat patients with high doses of vitamin D for various ailments without any monitoring for adverse effects and the prescribed doses often far exceed requirements resulting in toxicity. We present here a classic case of iatrogenic hypervitaminosis D, which presented with persistent vomiting and acute renal failure.
Here we present a case of a 45-year-old Asian Indian woman who presented to us with persistent vomiting the cause of which was iatrogenic hypervitaminosis D. She was treated with intravenous fluid, diuretics and calcitonin and had clinical improvement.
We suggest that in any patient presenting with persistent vomiting and hypercalcemia, particularly in the presence of normal parathyroid hormone, a diagnosis of overdose of vitamin D should be suspected. Its treatment not only alleviates symptoms but also prevents ongoing acute kidney injury.
维生素D的多种有益作用日益受到认可。维生素D缺乏症广泛存在。医生常常在未对不良反应进行任何监测的情况下,用高剂量维生素D治疗各种疾病,而且所开剂量常常远远超过需求,导致中毒。我们在此呈现一例医源性维生素D过多症的典型病例,该病例表现为持续性呕吐和急性肾衰竭。
我们在此介绍一名45岁的亚洲印度裔女性病例,她因医源性维生素D过多症前来就诊,症状为持续性呕吐。她接受了静脉输液、利尿剂和降钙素治疗,临床症状有所改善。
我们建议,对于任何出现持续性呕吐和高钙血症的患者,尤其是甲状旁腺激素正常的患者,应怀疑维生素D过量的诊断。其治疗不仅能缓解症状,还能预防持续的急性肾损伤。