Suppr超能文献

经前烦躁障碍中的社会刺激与皮质边缘反应性:一项初步研究。

Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder: a preliminary study.

作者信息

Gingnell Malin, Ahlstedt Victoria, Bannbers Elin, Wikström Johan, Sundström-Poromaa Inger, Fredrikson Mats

机构信息

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Department of Psychology, Uppsala University, Uppsala, Sweden.

出版信息

Biol Mood Anxiety Disord. 2014 Feb 26;4(1):3. doi: 10.1186/2045-5380-4-3.

Abstract

BACKGROUND

Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is generally linked to negative affect, increased amygdala reactivity to aversive stimuli in the luteal phase has not been consistently reported in PMDD. We tested the hypothesis that amygdala hyper-reactivity in PMDD is symptom specific, rather than generalized, and linked to socially relevant stimuli. Blood oxygenation level dependent signal changes during exposure to negative images with social and non-social content were evaluated in the mid-follicular and late luteal phase of the menstrual cycle. Fourteen women with PMDD and 13 healthy controls participated.

RESULTS

When compared with healthy controls, women with PMDD in the luteal phase had enhanced reactivity to social stimuli compared to non-social stimuli in the amygdala and insula, but attenuated reactivity in the anterior cingulate cortex. Functional couplings between emotion processing and controlling areas were significantly different, being positive in women with PMDD and negative in healthy controls. Changes in progesterone levels in women with PMDD correlated positively with altered amygdala reactivity.

CONCLUSIONS

Socially relevant aversive stimulation elicited enhanced activity in affective processing brain regions that were functionally coupled to compromised activity in cognitive control areas. Because increased reactivity correlated positively with alterations in ovarian steroid levels, data preliminary support the hypothesis that enhanced progesterone sensitivity in PMDD affects corticolimbic processing of social emotions.

摘要

背景

经前烦躁障碍(PMDD)以黄体期诱发的负面情绪和冲动控制丧失为特征,常导致社交互动受损。虽然杏仁核激活通常与负面情绪有关,但PMDD患者黄体期杏仁核对厌恶刺激的反应性增加尚未得到一致报道。我们检验了这样一个假设,即PMDD中的杏仁核高反应性是症状特异性的,而非全身性的,且与社会相关刺激有关。在月经周期的卵泡中期和黄体晚期,评估了暴露于具有社会和非社会内容的负面图像期间的血氧水平依赖信号变化。14名患有PMDD的女性和13名健康对照者参与了研究。

结果

与健康对照者相比,黄体期的PMDD女性杏仁核和脑岛对社会刺激的反应性比非社会刺激增强,但前扣带回皮质的反应性减弱。情绪处理和控制区域之间的功能耦合存在显著差异,在PMDD女性中为正,在健康对照者中为负。PMDD女性的孕酮水平变化与杏仁核反应性改变呈正相关。

结论

社会相关的厌恶刺激在情感处理脑区引发了增强的活动,这些脑区在功能上与认知控制区域受损的活动相关联。由于反应性增加与卵巢甾体水平的改变呈正相关,数据初步支持了这样的假设,即PMDD中孕酮敏感性增强会影响社会情绪的皮质边缘处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35de/4015856/cf8ebf9cdb3f/2045-5380-4-3-1.jpg

相似文献

1
Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder: a preliminary study.
Biol Mood Anxiety Disord. 2014 Feb 26;4(1):3. doi: 10.1186/2045-5380-4-3.
2
Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli.
Eur Neuropsychopharmacol. 2013 Nov;23(11):1474-83. doi: 10.1016/j.euroneuro.2013.08.002. Epub 2013 Aug 17.
3
Menstrual cycle effects on amygdala reactivity to emotional stimulation in premenstrual dysphoric disorder.
Horm Behav. 2012 Sep;62(4):400-6. doi: 10.1016/j.yhbeh.2012.07.005. Epub 2012 Jul 17.
5
Brain activation during emotion regulation in women with premenstrual dysphoric disorder.
Psychol Med. 2018 Aug;48(11):1795-1802. doi: 10.1017/S0033291717003270. Epub 2017 Nov 17.
7
The effect of premenstrual dysphoric disorder and menstrual cycle phase on brain activity during response inhibition.
J Affect Disord. 2012 Dec 15;142(1-3):347-50. doi: 10.1016/j.jad.2012.04.006. Epub 2012 Jul 27.
9
Aberrant Intrinsic Brain Network Functional Connectivity During a Face-Matching Task in Women Diagnosed With Premenstrual Dysphoric Disorder.
Biol Psychiatry. 2023 Sep 15;94(6):492-500. doi: 10.1016/j.biopsych.2023.04.001. Epub 2023 Apr 7.

引用本文的文献

1
Biomarkers of reproductive psychiatric disorders.
Br J Psychiatry. 2025 Jun;226(6):352-368. doi: 10.1192/bjp.2025.134. Epub 2025 Jun 20.
2
The role of the neuroinflammation and stressors in premenstrual syndrome/premenstrual dysphoric disorder: a review.
Front Endocrinol (Lausanne). 2025 Mar 28;16:1561848. doi: 10.3389/fendo.2025.1561848. eCollection 2025.
4
Jingqianshu granules mitigates premenstrual depression by regulating orexin signaling.
Front Pharmacol. 2024 Jun 14;15:1294122. doi: 10.3389/fphar.2024.1294122. eCollection 2024.
5
Diagnostic validity of premenstrual dysphoric disorder: revisited.
Front Glob Womens Health. 2023 Nov 27;4:1181583. doi: 10.3389/fgwh.2023.1181583. eCollection 2023.
9
Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.
Front Aging Neurosci. 2022 Jul 19;14:948219. doi: 10.3389/fnagi.2022.948219. eCollection 2022.

本文引用的文献

1
Neuroimaging in anxiety disorders.
Mod Trends Pharmacopsychiatry. 2013;29:47-66. doi: 10.1159/000351938. Epub 2013 Sep 20.
2
Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli.
Eur Neuropsychopharmacol. 2013 Nov;23(11):1474-83. doi: 10.1016/j.euroneuro.2013.08.002. Epub 2013 Aug 17.
6
Menstrual cycle effects on amygdala reactivity to emotional stimulation in premenstrual dysphoric disorder.
Horm Behav. 2012 Sep;62(4):400-6. doi: 10.1016/j.yhbeh.2012.07.005. Epub 2012 Jul 17.
7
Functional neuroimaging in specific phobia.
Psychiatry Res. 2012 Jun 30;202(3):181-97. doi: 10.1016/j.pscychresns.2011.10.009. Epub 2012 Jul 16.
8
Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies.
Neurosci Biobehav Rev. 2012 Oct;36(9):2130-42. doi: 10.1016/j.neubiorev.2012.06.003. Epub 2012 Jul 2.
9
Quantitative meta-analysis of neural activity in posttraumatic stress disorder.
Biol Mood Anxiety Disord. 2012 May 18;2:9. doi: 10.1186/2045-5380-2-9.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验