Long Jingyi, Wang Yuejie, Liu Lianzhong, Zhang Juan
Wuhan Mental Health Center, Wuhan, China.
Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Front Psychiatry. 2022 Jun 28;13:954211. doi: 10.3389/fpsyt.2022.954211. eCollection 2022.
Premenstrual syndrome (PMS) is a group of psychological, physical, and behavioral symptoms that recur with the menstrual cycle, usually occurring a few days before menstruation and ceasing with the onset of menstruation. Premenstrual dysphoric disorder (PMDD) is a severe form of PMS that has been included in a subcategory of depression in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) according to the latest diagnostic criteria. Patients usually present with mild to moderate emotional and physical symptoms that affect their routine work, social activities, and family lives. The pathogenesis of PMDD remains unclear, and some researchers believe that it is related to fluctuations in ovarian hormone levels. However, the details of the interrelationships and regulating effects between ovarian hormones, symptoms, and the brain need to be more comprehensively determined. Recent studies have revealed some novel findings on PMS and PMDD based on brain morphology, function, and metabolism. Additionally, multiple studies have suggested that PMS and PMDD are closely related to brain structural and functional variations in certain core temporal lobe regions, such as the amygdala and hippocampus. We summarized neuroimaging studies of PMS and PMDD related to the temporal lobe by retrospectively reviewing relevant literature over the past decade. This review contributes to further clarifying the significant role of the temporal lobe in PMS and PMDD and understanding the neurochemical links between hormones, symptoms, and the brain.
经前综合征（PMS）是一组在月经周期中反复出现的心理、身体和行为症状，通常在月经前几天出现，并在月经开始时消失。经前烦躁障碍（PMDD）是PMS的一种严重形式，根据最新诊断标准，已被纳入《精神疾病诊断与统计手册》（DSM-V）中的抑郁症子类别。患者通常会出现轻度至中度的情绪和身体症状，这些症状会影响他们的日常工作、社交活动和家庭生活。PMDD的发病机制尚不清楚，一些研究人员认为它与卵巢激素水平的波动有关。然而，卵巢激素、症状和大脑之间的相互关系及调节作用的细节仍需更全面地确定。最近的研究基于脑形态、功能和代谢揭示了一些关于PMS和PMDD的新发现。此外，多项研究表明，PMS和PMDD与某些核心颞叶区域（如杏仁核和海马体）的脑结构和功能变化密切相关。我们通过回顾过去十年的相关文献，总结了与颞叶相关的PMS和PMDD的神经影像学研究。这篇综述有助于进一步阐明颞叶在PMS和PMDD中的重要作用，并理解激素、症状和大脑之间的神经化学联系。
