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韩国人群样本中线粒体控制区的变异

Mitochondrial control region variation in a Korean population sample.

作者信息

Scheible Melissa, Kim Soon Hee, Sturk-Andreaggi Kimberly, Coble Michael D, Irwin Jodi A

机构信息

Armed Forces DNA Identification Laboratory, Armed Forces Medical Examiner System, 115 Purple Heart Drive, Dover, DE, 19902, USA.

出版信息

Int J Legal Med. 2014 Sep;128(5):745-6. doi: 10.1007/s00414-014-0963-7. Epub 2014 Feb 27.

Abstract

Mitochondrial DNA (mtDNA) control region (16024-576) sequences were generated from 281 individuals from South Korea. Robotic liquid handling, a redundant sequencing strategy, and a series of quality control checks were implemented to ensure the high quality of the dataset. This population sample showed a low random match probability (0.25 %) and high genetic diversity (0.9933). The haplogroup breakdown was consistent with previous studies describing Korean mtDNA variation. The 224 unique haplotypes (33 shared) presented will supplement the data already publically available.

摘要

从281名韩国个体中获取了线粒体DNA(mtDNA)控制区(16024 - 576)序列。采用了机器人液体处理技术、冗余测序策略以及一系列质量控制检查措施,以确保数据集的高质量。该人群样本显示出较低的随机匹配概率(0.25%)和较高的遗传多样性(0.9933)。单倍群分类与先前描述韩国人线粒体DNA变异的研究结果一致。所呈现的224个独特单倍型(33个共享单倍型)将补充已公开可用的数据。

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