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丙戊酸凝血障碍围手术期评估的注意事项。

Considerations in perioperative assessment of valproic acid coagulopathy.

作者信息

Abdallah Claude

机构信息

Department of Anesthesiology, Children's National Medical Center, The George Washington University Medical Center, NW Washington, DC, USA.

出版信息

J Anaesthesiol Clin Pharmacol. 2014 Jan;30(1):7-9. doi: 10.4103/0970-9185.125685.

DOI:10.4103/0970-9185.125685
PMID:24574585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3927296/
Abstract

Valproic acid (VPA) is one of the widely prescribed antiepileptic drugs in children with multiple indications. VPA-induced coagulopathy may occur and constitute a pharmacological and practical challenge affecting pre-operative evaluation and management of patients receiving VPA therapy. This review summarizes the different studies documenting the incidence, severity and available recommendations related to this adverse effect.

摘要

丙戊酸（VPA）是儿童中广泛处方的具有多种适应证的抗癫痫药物之一。VPA 诱导的凝血病可能发生，并构成一项药理学和实际挑战，影响接受 VPA 治疗患者的术前评估和管理。本综述总结了记录该不良反应的发生率、严重程度及现有建议的不同研究。

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本文引用的文献

1
[Evaluation of haemostasis in children treated with valproic acid].[丙戊酸治疗儿童的止血评估]
Hamostaseologie. 2010 Nov;30 Suppl 1:S132-7.
2
[Hemostatic disorders caused by chronic use of valproic acid in neurosurgical patients. Thromboelastographic monitoring].[神经外科患者长期使用丙戊酸引起的止血障碍。血栓弹力图监测]
Anesteziol Reanimatol. 2010 Jul-Aug(4):50-4.
3
Hematological effects of valproate in psychiatric patients: what are the risk factors?抗癫痫药物丙戊酸对精神科患者血液系统的影响：危险因素有哪些？
J Clin Psychopharmacol. 2010 Jun;30(3):282-5. doi: 10.1097/JCP.0b013e3181db2684.
4
Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition).抗栓或溶栓治疗患者的区域麻醉：美国区域麻醉与疼痛医学学会循证指南（第三版）。
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Valproate-associated coagulopathies in children during short-term treatment.儿童短期治疗期间与丙戊酸盐相关的凝血病
J Child Neurol. 2009 Dec;24(12):1493-8. doi: 10.1177/0883073808331084. Epub 2009 May 28.
6
High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study.接受丙戊酸治疗的儿童中丙戊酸盐诱导的凝血障碍发生率高：一项前瞻性研究。
Blood Coagul Fibrinolysis. 2008 Jul;19(5):375-82. doi: 10.1097/MBC.0b013e3282f3f9ec.
7
Severe bleeding complications during antiepileptic treatment with valproic acid in children.儿童使用丙戊酸进行抗癫痫治疗期间的严重出血并发症。
Neuropediatrics. 2007 Feb;38(1):42-5. doi: 10.1055/s-2007-981448.
8
Valproate-associated coagulopathies are frequent and variable in children.丙戊酸盐相关的凝血病在儿童中很常见且表现多样。
Epilepsia. 2006 Jul;47(7):1136-43. doi: 10.1111/j.1528-1167.2006.00587.x.
9
Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate.使用丙戊酸钠的癫痫儿童中的蛋白C、蛋白S及其他促凝血和抗凝血活性。
Brain Dev. 2006 Oct;28(9):549-53. doi: 10.1016/j.braindev.2006.03.009. Epub 2006 Jul 13.
10
Valproate-induced bleeding: report of two cases and review of literature.
Indian Pediatr. 2005 Aug;42(8):833-4.