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1
The mechanisms of inhibitory effects of liver extract on lymphocyte proliferation: II. Inhibition of DNA, RNA, and protein synthesis and their relationship to the effects of metabolic inhibitors.肝提取物对淋巴细胞增殖的抑制作用机制：II. 对DNA、RNA和蛋白质合成的抑制及其与代谢抑制剂作用的关系。
Clin Exp Immunol. 1988 May;72(2):228-32.
2
Inhibition of phytohaemagglutinin-induced autorosette formation of human peripheral blood lymphocytes by RNA or protein synthesis inhibitor.RNA或蛋白质合成抑制剂对植物血凝素诱导的人外周血淋巴细胞自身花环形成的抑制作用。
Clin Exp Immunol. 1983 Jul;53(1):140-4.
3
Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system.5-巯基-2'-脱氧尿苷对原代淋巴细胞培养系统中核苷掺入RNA和DNA的影响。
Cancer Res. 1976 Sep;36(9 pt.1):3284-93.
4
The mechanisms of the inhibitory effects of liver extract on lymphocyte proliferation. III. The effects of arginase on DNA polymerase activities.肝提取物对淋巴细胞增殖的抑制作用机制。III. 精氨酸酶对DNA聚合酶活性的影响。
Immunopharmacology. 1989 Sep-Oct;18(2):135-42. doi: 10.1016/0162-3109(89)90066-0.
5
Effects of metabolic inhibitors on spontaneous and interferon-boosted human natural killer cell activity.代谢抑制剂对人自然杀伤细胞自发活性及干扰素增强活性的影响。
J Immunol. 1980 Oct;125(4):1839-44.
6
Immuno-suppressive effect of human macrophages. II. Influence of macrophages on the kinetics of DNA, RNA and protein synthesis in PHA-stimulated lymphocytes.
Acta Pathol Microbiol Scand C. 1978 Aug;86C(4):187-92.
7
Inhibitory effects of dialyzed leukocyte extract on DNA and RNA synthesis.透析白细胞提取物对DNA和RNA合成的抑制作用。
Basic Appl Histochem. 1987;31(3):325-30.
8
[Effect of inhibitors of DNA and protein synthesis on production of mitogenic factor by human lymphocytes stimulated with phytohemagglutinin].
Biull Eksp Biol Med. 1976 Jul;82(7):829-31.
9
Stimulated rat T cell-derived inhibitory factor for cellular DNA synthesis (STIF). III. Effect on cell proliferation and immune responses.刺激大鼠T细胞来源的细胞DNA合成抑制因子（STIF）。III. 对细胞增殖和免疫反应的影响。
J Immunol. 1985 May;134(5):3172-8.
10
Metabolic inhibitors and kidney tubule induction.
Med Biol. 1978 Dec;56(6):372-9.

本文引用的文献

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Control of specific transfer RNA concentrations in amino acid-deprived Friend leukemia cells operates at the level of RNA degradation.在氨基酸缺乏的弗瑞德白血病细胞中，特定转运RNA浓度的调控作用于RNA降解水平。
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肝提取物对淋巴细胞增殖的抑制作用机制：II. 对DNA、RNA和蛋白质合成的抑制及其与代谢抑制剂作用的关系。

The mechanisms of inhibitory effects of liver extract on lymphocyte proliferation: II. Inhibition of DNA, RNA, and protein synthesis and their relationship to the effects of metabolic inhibitors.

作者信息

Su H L, Huang M H, Yu C L, Han S H, Chiang B N, Wang S R

机构信息

Department of Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.

出版信息

Clin Exp Immunol. 1988 May;72(2):228-32.

PMID:2457463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541524/
Abstract

The inhibitory effects of liver extract (LEx) on DNA, RNA, and protein synthesis in phytohaemagglutinin (PHA)-stimulated lymphocytes were studied by measuring the incorporation of labelled precursors. DNA, RNA, and protein synthesis were all inhibited by LEx in a dose-related manner. The inhibitory effect of LEx on protein synthesis was additive to the inhibitory effect of puromycin. The inhibitory effect of LEx on DNA synthesis was antagonistic to the inhibitory effect of mitomycin C. In the case of actinomycin D for RNA synthesis, its interactions with LEx were variable, but not additive. LEx may act as an inhibitor of protein synthesis through the mechanism of arginine-depletion.

摘要

通过测量标记前体的掺入，研究了肝提取物（LEx）对植物血凝素（PHA）刺激的淋巴细胞中DNA、RNA和蛋白质合成的抑制作用。LEx对DNA、RNA和蛋白质合成均有剂量依赖性抑制作用。LEx对蛋白质合成的抑制作用与嘌呤霉素的抑制作用相加。LEx对DNA合成的抑制作用与丝裂霉素C的抑制作用拮抗。对于放线菌素D对RNA合成的作用，其与LEx的相互作用是可变的，但不是相加的。LEx可能通过精氨酸耗竭机制作为蛋白质合成的抑制剂。