体外二次免疫应答过程中氨基酸缺乏及tRNA氨酰化对DNA合成和DNA聚合酶活性的影响。
Influence of amino acid deficiency and tRNA aminoacylation on DNA synthesis and DNA polymerase activity during the secondary immune response in vitro.
作者信息
Taudou G, Wiart J, Panijel J
出版信息
Mol Immunol. 1983 Mar;20(3):255-61. doi: 10.1016/0161-5890(83)90064-0.
PMID:6865951
Abstract
DNA synthesis and DNA polymerase activity are increased when KLH-primed guinea-pig lymphocytes are restimulated in vitro with the homologous antigen. This response can be modulated by glutamine deficiency and by an inhibitor of the histidyl-tRNA synthetase.
摘要
当用同源抗原在体外再次刺激用钥孔戚血蓝蛋白（KLH）致敏的豚鼠淋巴细胞时，DNA合成及DNA聚合酶活性会增加。这种反应可被谷氨酰胺缺乏以及组氨酰-tRNA合成酶抑制剂所调节。
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