在非霍奇金淋巴瘤和急性淋巴细胞白血病的强化长春新碱化疗期间对神经病变的评估。

Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and Acute Lymphoblastic Leukemia.

作者信息

Dorchin M, Masoumi Dehshiri R, Soleiman S, Manashi M

机构信息

Radiation Oncologist, Oncology Department, Dezfol University of Medical Sciences. Dezfol. Iran. ; HematoOncologist, Oncology department, Al-Bairouni University Hospital, Medical faculty, Damascus University, Damascus, Syria.

Health Policy Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

出版信息

Iran J Ped Hematol Oncol. 2013;3(4):138-42. Epub 2013 Oct 22.

PMID:24575286

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3915457/

Abstract

BACK GROUND

Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids.

MATERIALS AND METHODS

This study was a retrospective and descriptive study of neuropathy during in chemotherapy program with vincristine for patients with non-Hodgkin's lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL). Data was analyzed by spss Version16 software.

RESULTS

From total of 51 cases, 23 patients had vincristine neuropathy (45%). Patients with visceral neuropathy have shown ileus, constipation in 13 patients (25%), occasionally severe diarrhea 11 (21%), mild diarrhea 7 (13.7%) and transient diarrhea in 16 patients (31%). Motor neuropathy were found in one patient with Bell, s palsy (1.9%) and one patient with Hoarseness. 12 patients (23.5%) had some type of complication together with sensory peripheral neuropathy.

CONCLUSION

Almost half of patients with vincristin chemotherapy had neuropathy and the mean age of patients with neuropathy was 12.3 years.

摘要

背景

长春新碱（VCR）是一种化疗药物，可用于治疗白血病、淋巴瘤和实体瘤，它是一种强效神经毒素和感觉神经病变药物，这是该药物常见的行为毒性。神经病变是包含长春新碱和皮质类固醇的强化化疗方案常见的不良反应。

材料与方法

本研究是一项对非霍奇金淋巴瘤（NHL）和急性淋巴细胞白血病（ALL）患者使用长春新碱进行化疗期间神经病变的回顾性描述性研究。数据采用spss 16版软件进行分析。

结果

在总共51例病例中，23例患者出现长春新碱神经病变（45%）。内脏神经病变患者表现为肠梗阻，13例患者出现便秘（25%），偶尔严重腹泻11例（21%），轻度腹泻7例（13.7%），16例患者出现短暂腹泻（31%）。1例患者出现贝尔麻痹（1.9%）和1例患者出现声音嘶哑，存在运动神经病变。12例患者（23.5%）除感觉性周围神经病变外还出现了某种类型的并发症。