Cavaletti Guido, Frigeni Barbara, Lanzani Francesca, Piatti Marialuisa, Rota Stefania, Briani Chiara, Zara Gabriella, Plasmati Rosaria, Pastorelli Francesca, Caraceni Augusto, Pace Andrea, Manicone Mariagrazia, Lissoni Andrea, Colombo Nicoletta, Bianchi Giulia, Zanna Claudio
Dipartimento di Neuroscienze e Tecnologie Biomediche, Università di Milano Bicocca, Monza, Italy.
J Peripher Nerv Syst. 2007 Sep;12(3):210-5. doi: 10.1111/j.1529-8027.2007.00141.x.
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major side effect of several antineoplastic drugs. However, despite its clinical importance, there is no agreement as to the best way to assess the severity and changes in CIPN. We have previously demonstrated a correlation between the severity of CIPN, assessed using the Total Neuropathy Score (TNS) or its reduced versions, and several common toxicity scales. In this study, we investigated two series of patients (total number = 173) who were evaluated at baseline and during chemotherapy with the TNS (n= 122) or the TNSc (the TNS version based exclusively on the clinical evaluation of the patients, n= 51) and with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) 2.0, with the aim of comparing the sensitivity to the changes in CIPN severity. In both series, the TNS and the TNSc had a significant correlation with the NCI-CTC in scoring the severity of CIPN, confirming the results of previous studies. Moreover, both the TNS and the TNSc showed a higher sensitivity to CIPN changes. We, therefore, propose the TNSc as a reliable method for assessing not only the severity but also the changes in CIPN.
化疗引起的周围神经毒性（CIPN）是几种抗肿瘤药物的主要副作用。然而，尽管其具有临床重要性，但对于评估CIPN严重程度和变化的最佳方法尚无共识。我们之前已经证明，使用总神经病变评分（TNS）或其简化版本评估的CIPN严重程度与几种常见毒性量表之间存在相关性。在本研究中，我们调查了两组患者（总数 = 173），这些患者在基线期和化疗期间分别使用TNS（n = 122）或TNSc（仅基于患者临床评估的TNS版本，n = 51）以及美国国立癌症研究所通用毒性标准（NCI-CTC）2.0进行评估，目的是比较对CIPN严重程度变化的敏感性。在两个系列中，TNS和TNSc在对CIPN严重程度评分方面与NCI-CTC均具有显著相关性，证实了先前研究的结果。此外，TNS和TNSc对CIPN变化均表现出更高的敏感性。因此，我们建议将TNSc作为一种不仅可以评估CIPN严重程度，还可以评估其变化的可靠方法。
