用差分相移光学相干断层扫描测量热弹性位移以检测易损斑块。
Thermoelastic displacement measured by DP-OCT for detecting vulnerable plaques.
作者信息
Kim Jihoon, Kang Hyun Wook, Oh Junghwan, Milner Thomas E
机构信息
Fundamental Technology Group, Samsung-Electro Mechanics, Suwon 443-743, South Korea.
Department of Biomedical Engineering, Pukyong National University, Busan 608-737, South Korea ; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan 608-737, South Korea.
出版信息
Biomed Opt Express. 2014 Jan 14;5(2):474-84. doi: 10.1364/BOE.5.000474. eCollection 2014 Feb 1.
The detection of thermoelastic displacement by differential phase optical coherence tomography (DP-OCT) was analytically evaluated for identifying atherosclerotic plaques. Analytical solutions were developed to understand the dynamics of physical distribution of point hear sources during/after laser irradiation on thermoelastic responses of MION-injected tissue. Both analytical and experimental results demonstrated a delayed peak displacement along with slow decay after laser pulse due to heterogeneous distribution of the point heat sources. Detailed description of the heat sources in tissue as well as integration of a scanning mirror can improve computational accuracy as well as clinical applicability of DP-OCT for diagnosing vulnerable plaque.
通过差分相移光学相干断层扫描（DP-OCT）检测热弹性位移，对识别动脉粥样硬化斑块进行了分析评估。开发了解析解，以了解在激光照射MION注射组织的热弹性响应期间/之后点热源物理分布的动态变化。分析和实验结果均表明，由于点热源的不均匀分布，激光脉冲后出现延迟的峰值位移以及缓慢的衰减。详细描述组织中的热源以及集成扫描镜可以提高DP-OCT诊断易损斑块的计算准确性和临床适用性。
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