母体乙醇暴露对胎儿脑生物胺代谢产物的影响。

Alterations of fetal brain biogenic amine metabolites by maternal ethanol exposure.

Okonmah A D, Brown J W, Owasoyo J O, Soliman K F

College of Pharmacy, Florida A & M University, Clinical Research Unit, Miami 33142.

Gen Pharmacol. 1988;19(4):589-93. doi: 10.1016/0306-3623(88)90169-3.

Abstract

Pregnant Sprague-Dawley rats treated chronically with ethanol (3 g/kg daily for the last third of pregnancy) had decreased placental weights at birth (ca 23%). 2. Whole fetal brain levels of HVA and 5-HIAA were similarly decreased 32 and 38%, respectively. 3. MHPG levels were also marginally reduced (i.e. 15% decline). 4. In the presence of a potent type A MAO inhibitor (harmaline, 10 mg/kg maternal weight 2 hr before fetal delivery) co-treatment with ethanol was found to result in a 60% elevation of whole fetal brain norepinephrine levels. 5. Other biogenic amines and metabolites were not altered by ethanol treatment.

摘要

在孕期最后三分之一阶段每天慢性给予乙醇（3克/千克）处理的怀孕斯普拉格-道利大鼠，出生时胎盘重量降低（约23%）。2. 全胎脑的高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）水平分别同样降低了32%和38%。3. 3-甲氧基-4-羟苯乙二醇（MHPG）水平也略有降低（即下降15%）。4. 在强效A型单胺氧化酶（MAO）抑制剂（哈马灵，胎儿分娩前2小时母体体重10毫克/千克）存在的情况下，发现乙醇联合处理导致全胎脑去甲肾上腺素水平升高60%。5. 乙醇处理未改变其他生物胺及其代谢产物。