Peters D A
Pharmacol Biochem Behav. 1982 Oct;17(4):721-5. doi: 10.1016/0091-3057(82)90353-7.
Pregnant rats were subjected to once daily stress treatments consisting of handling and a saline injection. The offspring showed region-specific changes in brain 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) levels in infancy but only the hypothalamus still showed significant changes at 60 days of age. In a reaction-to-stress test 23-day-old offspring in the prenatal stress group showed a greater elevation in plasma corticosterone level but smaller changes in hypothalamic NE and 5-HIAA levels than control offspring suggesting that prenatal stress may have altered the functioning of the hypothalamic-pituitary-adrenal axis. It is suggested that changes in the development of specific monoamine-containing neurons may be associated with the reported behavioral deficits in offspring of female rats stressed during pregnancy.
将怀孕大鼠每天进行一次应激处理，包括抓取和注射生理盐水。其后代在婴儿期大脑5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）和去甲肾上腺素（NE）水平出现区域特异性变化，但仅下丘脑在60日龄时仍显示出显著变化。在应激反应测试中，产前应激组23日龄的后代血浆皮质酮水平升高幅度更大，但下丘脑NE和5-HIAA水平的变化比对照后代小，这表明产前应激可能改变了下丘脑-垂体-肾上腺轴的功能。有人认为，特定含单胺神经元发育的变化可能与孕期应激雌性大鼠后代所报告的行为缺陷有关。
