Vakhapova Veronika, Cohen Tzafra, Richter Yael, Herzog Yael, Kam Yossi, Korczyn Amos D
Neurology Consultant, Maccabi Health Services, Tel Aviv, Israel.
Dement Geriatr Cogn Disord. 2014;38(1-2):39-45. doi: 10.1159/000357793. Epub 2014 Feb 20.
The present study is an open-label extension (OLE) aimed at evaluating the effect of 100 mg/day of phosphatidylserine enriched with docosahexaenoic acid (PS-DHA) on cognitive performance in nondemented elderly individuals with memory complaints.
From the participants who completed the core study, 122 continued with a 15-week OLE. Efficacy was assessed using a computerized tool and the Clinical Global Impression of Change (CGI-C) rating scale.
A significant improvement in sustained attention and memory recognition was observed in the PS-DHA naïve group, while the PS-DHA continuers maintained their cognitive status. Additionally, a significant improvement in CGI-C was observed in the naïve group.
The results demonstrate that consumption of 100 mg/day of PS-DHA might be associated with improving or maintaining cognitive status in elderly subjects with memory complaints.
本研究是一项开放标签扩展试验（OLE），旨在评估每日100毫克富含二十二碳六烯酸的磷脂酰丝氨酸（PS-DHA）对有记忆障碍的非痴呆老年人认知能力的影响。
从完成核心研究的参与者中，122人继续进行为期15周的开放标签扩展试验。使用计算机化工具和临床总体印象变化量表（CGI-C）评估疗效。
在初次使用PS-DHA的组中，持续注意力和记忆识别能力有显著改善，而继续使用PS-DHA的组保持了他们的认知状态。此外，初次使用PS-DHA的组在CGI-C上有显著改善。
结果表明，每日服用100毫克PS-DHA可能与改善或维持有记忆障碍的老年受试者的认知状态有关。
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