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甲状腺原发性结核:甲状腺毒症的意外病因。

Primary tuberculosis of the thyroid gland: an unexpected cause of thyrotoxicosis.

作者信息

Raman Lavanya, Murray James, Banka Rajesh

机构信息

Department of Respiratory, King George Hospital, London, UK.

出版信息

BMJ Case Rep. 2014 Feb 27;2014:bcr2013202792. doi: 10.1136/bcr-2013-202792.

DOI:10.1136/bcr-2013-202792
PMID:24577178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3939388/
Abstract

We describe a 38-year-old Indian man who presented with a 2-week history of fever, night sweats and neck swelling who was found to be clinically thyrotoxic with a nodular goitre, tachycardia and high fever. Biochemical investigation revealed hyperthyroidism in association with deranged liver function tests and raised inflammatory markers. Ultrasound and CT scans of the neck revealed multinodular thyroid enlargement. He was considered most likely to have an acute infectious thyroiditis with a differential diagnosis of a toxic multinodular goitre and was started on carbimazole and antibiotics. He underwent fine needle aspiration of the thyroid which revealed necrotic cells and acid-fast bacilli, confirming a diagnosis of primary tuberculosis (TB) of the thyroid gland with no evidence of any other organ involvement on systemic imaging. He was started on TB therapy for 6 months and discharged with outpatient follow-up. Symptoms and biochemical markers subsequently resolved.

摘要

我们描述了一名38岁的印度男性,他有2周的发热、盗汗和颈部肿胀病史,临床检查发现患有甲状腺毒症,伴有结节性甲状腺肿、心动过速和高热。生化检查显示甲状腺功能亢进,同时肝功能检查异常且炎症标志物升高。颈部超声和CT扫描显示甲状腺多结节性肿大。他被认为最有可能患有急性感染性甲状腺炎,鉴别诊断为毒性多结节性甲状腺肿,并开始服用卡比马唑和抗生素。他接受了甲状腺细针穿刺,结果显示有坏死细胞和抗酸杆菌,确诊为甲状腺原发性结核,全身影像学检查未发现其他器官受累的证据。他开始接受为期6个月的抗结核治疗,出院后进行门诊随访。症状和生化指标随后得到缓解。

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本文引用的文献

1
Resistance in tuberculosis: what do we know and where can we go?结核病耐药性:我们了解多少?我们的前路在何方?
Front Microbiol. 2013 Jul 23;4:208. doi: 10.3389/fmicb.2013.00208. eCollection 2013.
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Primary tuberculosis of the thyroid gland: a case report.甲状腺原发性结核:一例报告
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Thyroid tuberculosis: a case series and a review of the literature.甲状腺结核:病例系列及文献综述
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Tuberculosis of the thyroid presenting as multinodular goiter with hypothyroidism: a rare presentation.表现为多结节性甲状腺肿伴甲状腺功能减退的甲状腺结核:一种罕见的表现。
Indian J Pathol Microbiol. 2010 Jul-Sep;53(3):579-81. doi: 10.4103/0377-4929.68256.
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Tuberculous infection of thyroid gland: a case report.甲状腺结核感染:一例报告
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Global epidemiology of tuberculosis: prospects for control.全球结核病流行病学:控制前景
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TUBERCULOSIS OF THE THYROID GLAND.甲状腺结核
Ann Surg. 1932 Oct;96(4):625-48. doi: 10.1097/00000658-193210000-00013.
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Thyroid tuberculosis.甲状腺结核
Hormones (Athens). 2007 Jan-Mar;6(1):75-9.