鲑鱼降钙素可诱发大鼠头部抽搐。

Salmon calcitonin induced head twitch in the rat.

作者信息

Gaggi R, De Iasio R

机构信息

Institute of Pharmacology, University of Bologna, School of Medicine, Italy.

出版信息

Jpn J Pharmacol. 1988 May;47(1):87-90. doi: 10.1254/jjp.47.87.

DOI:10.1254/jjp.47.87

PMID:2457726

Abstract

The intracerebroventricular administration of salmon calcitonin (sCT) to rats induced a dose-dependent increase in the number of head twitches and potentiated such a response elicited by L-5-hydroxytryptophan (L-5-HTP). Subcutaneously administered sCT was ineffective "per se" but could again potentiate the head twitch response elicited by L-5-HTP. Since these data suggest a stimulation of the brain serotonergic pathways, the obtained results support the hypothesis that some central actions of sCT may involve activation of serotonergic systems in the rat brain.

摘要

向大鼠脑室内注射鲑鱼降钙素（sCT）会导致头部抽搐次数呈剂量依赖性增加，并增强由L-5-羟色氨酸（L-5-HTP）引发的这种反应。皮下注射sCT本身无效，但仍可增强由L-5-HTP引发的头部抽搐反应。由于这些数据表明大脑中5-羟色胺能通路受到刺激，因此所获得的结果支持这样一种假说，即sCT的某些中枢作用可能涉及大鼠脑中5-羟色胺能系统的激活。