Twery M J, Cooper C W, Mailman R B
Pharmacol Biochem Behav. 1983 Jun;18(6):857-62. doi: 10.1016/s0091-3057(83)80005-7.
Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 micrograms/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.
合成鲑鱼降钙素（sCT），皮下注射（6.4微克/千克）或脑室内注射（ICV，30 - 600纳克），可使大鼠中苯丙胺诱导的运动活性降低超过50%。在腹腔注射苯丙胺（1 - 3毫克/千克）前三小时或即将注射前脑室内注射sCT，可显著降低苯丙胺诱导的活性。在没有苯丙胺的情况下，sCT在治疗后的前100分钟内对运动活性没有影响。这些结果表明sCT可在中枢发挥作用以改变药物诱导的行为，这可能与大脑中降钙素受体和降钙素样肽的报道有关。
