Jeon Y K, Shin M J, Kim W J, Kim S S, Kim B H, Kim S J, Kim Y K, Shin Y B, Kim I J
Division of Endocrinology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Osteoporos Int. 2014 May;25(5):1571-6. doi: 10.1007/s00198-014-2627-3. Epub 2014 Feb 28.
The aim of this study was to examine the association between pulmonary function and bone mineral density (BMD) in subjects who had never smoked. Pulmonary function was associated with BMD in premenopausal, but not postmenopausal, women.
It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy nonsmoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy nonsmoking women based on menopausal status.
This study was a cross-sectional study based on data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES), a nationwide representative survey conducted by the Korean Ministry of Health and Welfare in 2010. This study included 456 subjects who had never smoked and analyzed data concerning pulmonary function and BMD.
Functional vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were correlated with BMD at lumbar spine, femur neck (FN), and total hip in premenopausal women (p = 0.030, p = 0.003, p = 0.019, respectively, for FVC; p = 0.015, p = 0.006, p = 0.059, respectively, for FEV1). However, FVC and FEV1 were only correlated with BMD at FN in postmenopausal women (p = 0.003 for FVC; p = 0.006 for FEV1). Body mass index (BMI), FVC, and FEV1 were significantly related with BMD at FN, even after adjusting for age and other confounding factors (β = 0.334, p < 0.001; β = 0.145, p = 0.017; and β = 0.129, p = 0.037, respectively) in premenopausal women. However, only age and BMI were correlated with BMD at FN (β = -0.268, p = 0.001 and β = 0.384, p > 0.001) in postmenopausal women after adjusting for confounding factors.
Pulmonary function, including FVC and FEV1 are associated with BMD at FN in healthy nonsmoking premenopausal women but not in postmenopausal women.
本研究的目的是在从不吸烟的受试者中检验肺功能与骨矿物质密度（BMD）之间的关联。在绝经前女性中，肺功能与骨矿物质密度相关，但在绝经后女性中并非如此。
据报道，低骨量在慢性阻塞性肺疾病等肺部疾病患者中很常见。然而，在健康的非吸烟女性中，骨量与肺功能之间的关系尚未明确。本研究的目的是根据绝经状态确定健康的非吸烟女性的肺功能是否与骨矿物质密度相关。
本研究是一项横断面研究，基于从韩国国家健康与营养检查调查（KNHANES）获得的数据，这是韩国卫生与福利部在2010年进行的一项全国代表性调查。本研究纳入了456名从不吸烟的受试者，并分析了有关肺功能和骨矿物质密度的数据。
在绝经前女性中，功能肺活量（FVC）和第1秒用力呼气量（FEV1）与腰椎、股骨颈（FN）和全髋部的骨矿物质密度相关（FVC分别为p = 0.030、p = 0.003、p = 0.019；FEV1分别为p = 0.015、p = 0.006、p = 0.059）。然而，在绝经后女性中，FVC和FEV1仅与FN处的骨矿物质密度相关（FVC为p = 0.003；FEV1为p = 0.006）。即使在调整年龄和其他混杂因素后，体重指数（BMI）、FVC和FEV1在绝经前女性中仍与FN处的骨矿物质密度显著相关（β = 0.334，p < 0.001；β = 0.145，p = 0.017；β = 0.129，p = 0.037）。然而，在绝经后女性中，调整混杂因素后，只有年龄和BMI与FN处的骨矿物质密度相关（β = -0.268，p = 0.001和β = 0.384，p > 0.001）。
在健康的非吸烟绝经前女性中，但不是绝经后女性中，包括FVC和FEV1在内的肺功能与FN处的骨矿物质密度相关。
