Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
BMC Musculoskelet Disord. 2013 Aug 23;14:253. doi: 10.1186/1471-2474-14-253.
Physical activity is known to benefit many physiological processes, including bone turnover. There are; however, currently no clinical guidelines regarding the most appropriate type, intensity and duration of activity to prevent bone loss.
To help address this gap in the literature, we performed a retrospective analysis of data from the Canadian Multicentre Osteoporosis Study (CaMos), a prospective cohort of 9423 adult patients, to determine the relationship between the amount of regular daily physical activity performed and bone mineral density. A total of 1169 female participants aged 75 and over provided information regarding their daily activity levels, including the amount of time spent each week performing physical activity at varying levels of intensity. Multiple and linear regression analyses were used to determine the effect of increasing amounts of this regular physical activity on bone mineral density.
The results indicate that a step increase in the amount of physical activity performed each day resulted in a positive effect on bone mineral density at the hip, Ward's triangle, trochanter and femoral neck (B = 0.006 to 0.008, p < 0.05). Possible confounding factors such as the use of anti-resorptive therapy, body mass index and age were included in the analysis and suggested that age had a negative effect on bone density while body mass index had a positive effect. Anti-resorptive therapy provided a protective effect against loss of bone density.
The data indicate that a step increase in the amount of daily activity, using simple, daily performed tasks, can help prevent decreases in post-menopausal bone mineral density.
体力活动有益于许多生理过程,包括骨转换。然而,目前没有关于预防骨质流失的最合适的活动类型、强度和持续时间的临床指南。
为了帮助解决文献中的这一空白,我们对加拿大骨质疏松多中心研究(CaMos)的数据进行了回顾性分析,该研究是一项针对 9423 名成年患者的前瞻性队列研究,以确定进行的日常体力活动量与骨密度之间的关系。共有 1169 名年龄在 75 岁及以上的女性参与者提供了有关其日常活动水平的信息,包括每周进行不同强度体力活动的时间。多元和线性回归分析用于确定这种日常体力活动量的增加对骨密度的影响。
结果表明,每天进行的体力活动量增加一个台阶,会对髋部、Ward 三角区、转子间和股骨颈的骨密度产生积极影响(B = 0.006 至 0.008,p < 0.05)。分析中包括了可能的混杂因素,如使用抗吸收药物、体重指数和年龄,结果表明年龄对骨密度有负面影响,而体重指数有正面影响。抗吸收药物对防止骨密度下降有保护作用。
数据表明,日常活动量的增加,即使是使用简单的日常活动,也有助于预防绝经后骨密度的下降。