直接合成四元含硫杂环：介绍一种对环丁砜1-氧化物进行单官能化和双官能化的策略。
Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide.
作者信息
Carroccia Laura, Degennaro Leonardo, Romanazzi Giuseppe, Cuocci Corrado, Pisano Luisa, Luisi Renzo
机构信息
Department of Pharmacy - Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, Bari 70125 - I, Italy.
出版信息
Org Biomol Chem. 2014 Apr 14;12(14):2180-4. doi: 10.1039/c4ob00173g.
PMID:24577375
Abstract
A strategy for the stereoselective functionalization of thietane 1-oxide has been developed. Mono (C2 substituted) and doubly (C2, C4 disubstituted) functionalized thietanes have been obtained from the readily available thietane 1-oxide by using the corresponding organometallic intermediates that reacted with electrophiles leaving intact the 4-membered ring.
摘要
已开发出一种对硫杂环丙烷1-氧化物进行立体选择性官能化的策略。通过使用与亲电试剂反应的相应有机金属中间体，从容易获得的硫杂环丙烷1-氧化物中获得了单（C2取代）和双（C2、C4二取代）官能化的硫杂环丙烷，同时保持四元环完整。
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