Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Chem Commun (Camb). 2014 Apr 11;50(28):3725-8. doi: 10.1039/c4cc00297k.
Intermolecular Heck reaction of common alkyl halides, a longstanding problem in palladium catalysis, is realized with a simple Pd/dppf catalyst. Both primary and secondary alkyl halides are suitable for coupling with aromatic olefins. Single electron transfer from (dppf)Pd(0) to alkyl halide initiated the catalytic cycle and gave alkyl radicals.
常见卤代烷烃的分子间 Heck 反应是钯催化中的一个长期存在的问题，现在使用一种简单的 Pd/dppf 催化剂即可实现。伯卤代烷烃和仲卤代烷烃都适合与芳基烯烃偶联。(dppf)Pd(0) 向卤代烷烃发生单电子转移引发催化循环并生成烷基自由基。
