Silverstein Jeffrey H
Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Alzheimers Dis. 2014;40(4):839-48. doi: 10.3233/JAD-130815.
Since the finding in the 1880 s that elderly patients may experience cognitive decline following surgery, the search for an understanding of this phenomenon has been underway. In the last decade, evidence from biophysical (light scattering and nuclear magnetic resonance), in vitro, in vivo animal studies, retrospective evaluations of human registries, and recently prospective randomized trials have explored the idea that various anesthetic agents play a role in this phenomenon by interacting with the biochemical mechanisms that are also responsible for the development of Alzheimer's disease. In the current review, we examine the evidence available and conclude that there is significant evidence to suggest an important role for this mechanism.
自19世纪80年代发现老年患者术后可能出现认知功能衰退以来，人们一直在探寻对这一现象的理解。在过去十年中，来自生物物理学（光散射和核磁共振）、体外、体内动物研究、人类登记处的回顾性评估以及最近的前瞻性随机试验的证据，探讨了各种麻醉剂通过与也导致阿尔茨海默病发展的生化机制相互作用，在这一现象中发挥作用的观点。在本综述中，我们审视了现有的证据，并得出结论：有大量证据表明这一机制发挥着重要作用。
