Steffen R P, O'Neill J T, Haddy F J
Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
J Cardiovasc Pharmacol. 1988 Jun;11(6):682-6. doi: 10.1097/00005344-198806000-00008.
To examine the possible role of adenosine in the vasoactivity of acetate, acetate and adenosine were injected into the renal artery of the dog while measuring renal blood flow. Low (9-28 mg) doses of acetate produced vasodilation, but higher doses (28-94 mg), like adenosine, produced vasoconstriction followed by vasodilation. Theophylline, a competitive inhibitor of the vascular action of adenosine, inhibited the vasodilator action of adenosine but not that of acetate. Secondly, theophylline inhibited the vasoconstrictor effect of adenosine and acetate but the latter to a much lesser extent. These findings suggest that adenosine mediates the vasoconstriction effect of acetate in the canine kidney.
为研究腺苷在乙酸盐血管活性中可能发挥的作用，在测量肾血流量的同时，将乙酸盐和腺苷注入犬的肾动脉。低剂量（9 - 28毫克）的乙酸盐可引起血管舒张，但高剂量（28 - 94毫克）的乙酸盐则像腺苷一样，先引起血管收缩，随后血管舒张。茶碱是腺苷血管作用的竞争性抑制剂，它抑制腺苷的血管舒张作用，但不抑制乙酸盐的血管舒张作用。其次，茶碱抑制腺苷和乙酸盐的血管收缩作用，但对乙酸盐的抑制作用程度要小得多。这些发现表明，腺苷介导了乙酸盐在犬肾中的血管收缩作用。
