Yamada N, Bünger R, Steinhart C R, Olsson R A
Basic Res Cardiol. 1986 Jul-Aug;81(4):342-9. doi: 10.1007/BF01907455.
This study compares the coronary vasoactivity of acetate in the blood-perfused heart of the open-chest dog and in the buffer-perfused guinea-pig heart. In the dog acetate is a weak but probably fully efficacious coronary agonist. Direct intracoronary infusions of isosmolar Na acetate caused dose-dependent coronary vasodilation and decreased transcoronary O2 extraction, resulting in an increase in cardiac O2 usage of up to 40%. Acetate raised coronary flow to at least 50% above control in 63 of 67 dogs but caused maximum coronary vasodilation (400% of control) in only 39 of the 67. The frequency distribution of the acetate EC-20 decreased monotonically from a mode at less than 1 mM over a range extending to greater than 6 mM, suggesting a single population of animals characterized by a rather wide range of sensitivity to acetate. Theophylline antagonized acetate vasodilation, in support of the idea that adenosine mediates the coronary effects of acetate. In the guinea-pig heart, acetate in concentrations up to 10 mM caused minimal increases in coronary flow that were completely accounted for by the small change in O2 usage that resulted from switching from glucose to acetate the main energy source. Acetate (10 mM) elicited a small release of adenosine and its degradation products.
本研究比较了乙酸盐在开胸犬血液灌注心脏和缓冲液灌注豚鼠心脏中的冠状血管活性。在犬中，乙酸盐是一种弱的但可能完全有效的冠状激动剂。等渗醋酸钠的直接冠状动脉内输注引起剂量依赖性冠状动脉舒张，并降低冠状动脉氧摄取，导致心脏氧利用增加高达40%。在67只犬中的63只中，乙酸盐使冠状动脉血流至少比对照增加50%，但在67只中只有39只引起最大冠状动脉舒张（对照的400%）。乙酸盐EC-20的频率分布从小于1 mM的众数单调下降，范围延伸至大于6 mM，表明存在一群对乙酸盐敏感性范围相当宽的动物。茶碱拮抗乙酸盐舒张血管作用，支持腺苷介导乙酸盐冠状效应的观点。在豚鼠心脏中，浓度高达10 mM的乙酸盐引起冠状动脉血流的最小增加，这完全由从葡萄糖切换到主要能量来源乙酸盐导致的氧利用的微小变化所解释。乙酸盐（10 mM）引起少量腺苷及其降解产物的释放。
