槟榔二氯甲烷提取物对啮齿动物单胺相关行为及酪胺升压敏感性的影响

Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents.

作者信息

Khan Shagufta, Abbas Ghulam, Ahmed Fahad Shabbir, Rahman Attaur, Dar Ahsana

机构信息

Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Medical College, Karachi, Pakistan.

Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.

出版信息

Pak J Pharm Sci. 2014 Mar;27(2):303-7.

PMID:24577919

Abstract

The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.

摘要

本研究旨在探讨槟榔二氯甲烷提取物（7毫克/千克）对单胺类物质（血清素和多巴胺）调节作用（5-羟色氨酸诱导的震颤和苯乙胺诱导的刻板行为）的影响及其与酪胺的相互作用（奶酪效应）。二氯甲烷提取物导致5-羟色氨酸诱导的震颤显著增加（50%），而苯乙胺诱导的刻板行为增加可忽略不计（20%）。此外，它并未使酪胺升压效应显著增加。这些结果表明，槟榔二氯甲烷提取物主要提高血清素水平（可能通过抑制单胺氧化酶A），且不会诱发奶酪效应。