Qazi Nasreen, Khan Rafeeq Alam, Rizwani Ghazala H, Feroz Zeeshan
Department of Pharmacology, Liaqat University of Medical and Health Sciences, Jamshoro, Pakistan.
Department of Basic Medical Sciences, College of Medicine-Jeddah, King Saud Bin Abdulaziz University for Health Sciences, Kingdom of Saudi Arabia.
Pak J Pharm Sci. 2014 Mar;27(2):377-80.
Diabetes mellitus is a major threat to present and future generations. The role of herbal medication has emerged as a safe alternative to currently available medication due to its decreased potential to produce side effects, hence effect of Carthamus tinctorius was observed on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits. Thirty five healthy male rabbits were divided into 5 groups with 7 rabbits in each (Normal control, diabetic control, diabetic treated with glibenclamide, diabetic treated with Carthamus tinctorius extract at doses of 200 and 300mg/kg of body weight). Drug and extract were given orally for 30 days and the values for blood glucose levels were observed after 15(th) and 30(th) day of treatment by using standard reagent kits provided by Human Germany. While insulin levels were checked at the end of the study by using Architect i1000 by Abbott Diagnostics USA. Animals were also observed for any gross toxicity during the study. Results revealed that Carthamus tinctorius has significant hypoglycemic effect at 200mg/kg and 300mg/kg doses as compared to diabetic control group. Insulin levels were significantly increased in Glibenclamide treated as well as Carthamus tinctorius treated groups as compared to diabetic control.
糖尿病对当代及后代都是重大威胁。草药疗法因其产生副作用的可能性较低，已成为现有药物的一种安全替代方案，因此观察了红花对四氧嘧啶诱导的糖尿病兔空腹血糖和胰岛素水平的影响。将35只健康雄性兔分为5组，每组7只（正常对照组、糖尿病对照组、用格列本脲治疗的糖尿病组、用200和300mg/kg体重剂量的红花提取物治疗的糖尿病组）。药物和提取物口服30天，在治疗的第15天和第30天后，使用德国Human公司提供的标准试剂盒观察血糖水平值。而胰岛素水平在研究结束时使用美国雅培诊断公司的Architect i1000进行检测。在研究期间还观察动物是否有任何明显的毒性。结果显示，与糖尿病对照组相比，红花在200mg/kg和300mg/kg剂量时有显著的降血糖作用。与糖尿病对照组相比，格列本脲治疗组和红花治疗组的胰岛素水平显著升高。
